Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module (2024)

Lee, H., Song, C., Hong, Y. S., Kim, M. S., Cho, H. R., Kang, T., Shin, K., Choi, S. H., Hyeon, T., & Kim, D. H. (2017). Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Science Advances, 3(3), Article e1601314. https://doi.org/10.1126/sciadv.1601314

Lee, Hyunjae ; Song, Changyeong ; Hong, Yong Seok et al. / Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. In: Science Advances. 2017 ; Vol. 3, No. 3.

@article{b171eeded42f47069b84c1a44d190103,

title = "Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module",

abstract = "Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient{\textquoteright}s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.",

author = "Hyunjae Lee and Changyeong Song and Hong, {Yong Seok} and Kim, {Min Sung} and Cho, {Hye Rim} and Taegyu Kang and Kwangsoo Shin and Choi, {Seung Hong} and Taeghwan Hyeon and Kim, {Dae Hyeong}",

note = "Publisher Copyright: 2017 {\textcopyright} The Authors, some rights reserved.",

year = "2017",

month = mar,

doi = "10.1126/sciadv.1601314",

language = "English",

volume = "3",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "3",

}

Lee, H, Song, C, Hong, YS, Kim, MS, Cho, HR, Kang, T, Shin, K, Choi, SH, Hyeon, T & Kim, DH 2017, 'Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module', Science Advances, vol. 3, no. 3, e1601314. https://doi.org/10.1126/sciadv.1601314

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. / Lee, Hyunjae; Song, Changyeong; Hong, Yong Seok et al.
In: Science Advances, Vol. 3, No. 3, e1601314, 03.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

AU - Lee, Hyunjae

AU - Song, Changyeong

AU - Hong, Yong Seok

AU - Kim, Min Sung

AU - Cho, Hye Rim

AU - Kang, Taegyu

AU - Shin, Kwangsoo

AU - Choi, Seung Hong

AU - Hyeon, Taeghwan

AU - Kim, Dae Hyeong

N1 - Publisher Copyright:2017 © The Authors, some rights reserved.

PY - 2017/3

Y1 - 2017/3

N2 - Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.

AB - Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=85041738561&partnerID=8YFLogxK

U2 - 10.1126/sciadv.1601314

DO - 10.1126/sciadv.1601314

M3 - Article

C2 - 28345030

AN - SCOPUS:85041738561

SN - 2375-2548

VL - 3

JO - Science Advances

JF - Science Advances

IS - 3

M1 - e1601314

ER -

Lee H, Song C, Hong YS, Kim MS, Cho HR, Kang T et al. Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Science Advances. 2017 Mar;3(3):e1601314. doi: 10.1126/sciadv.1601314